PRESENTATION
DUO-COTECXIN® TABLETS
For Adult
(Dihydroartemisinin 40mg + Piperaquine Phosphate 320mg)
8 Tablets/Packet, 480Pkts/Carton
PHARMACOLOGY
DUO-COTECXIN® is a synergistic combination of an artemisinin derivative and a new bisquinoline compound; it is active against the asexual forms of plasmodium, schizonts and gametocytes. Its action on schizonts insures a rapid decrease of pathogenic parasitaemia which leads to a quick disappearance of clinical signs; its action on gametocytes prevents contamination.
The absorption of DUO-COTECXIN® after oral intake is rapid and complete; it is extensively distributed in all tissues. Half life of DHA is very short (around 2 hours) whereas PPQ is long (around 9 days).
INDICATIONS
DUO-COTECXIN® is indicated for the treatment of all kinds of malaria, as long as patients can take oral medications. It is particularly recommended in the case of multi-resistant plasmodium falciparum malaria.
ADMINISTRATION AND DOSAGE
Oral administration.
Patient should follow doctor’s instruction. The recommended dosage is in the following table:
|
|
Adults |
Children 16 - 11 |
Children 11 - 6 |
|
Day 1 |
3 tabs |
2 tabs |
1.5 tab |
|
Day 2 |
3 tabs |
2 tabs |
1.5 tab |
|
Day 3 |
2 tabs |
2 tabs |
1 tab |
|
Total |
8 tabs |
6 tabs |
4 tabs |
ADVERSE EFFECTS
Few cases of adverse effects have been reported after administration of DUO-COTECXIN®. Most of them are related to PPQ affecting the digestive tract (nausea, diarrhea, loss of appetite, etc.). Rare allergic reactions have also been reported (rash, pruritus, etc.).
CONTRAINDICATIONS
As all new drugs, DUO-COTECXIN® is not recommended during the first trimester of pregnancy unless your doctor considers the risk of the disease to be greater.
A new course of DUO-COTECXIN® should not be taken within four weeks after the first treatment.
STORAGE
Keep all medicines out of the reach of children.
Preserve in tight and lightproof containers.
Store in a cool and dry place below 30℃.
SHELF LIFE
2 years.